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Frailty and the Endocrine System

by Dr Agnieszka Swiecicka-Mitsides, Assistant Professor, Department of Basic and Clinical Sciences, University of Nicosia Medical School.

With a growing ageing population worldwide, frailty and its consequences are now of growing interest to healthcare systems and researchers. Even though the recognition of the affected or ‘at-risk’ individuals has greatly improved in recent years, the relative lack of effective treatment strategies, largely due to a poorly understood pathophysiology of frailty, has affected the progress in this area. My research explores frailty in the context of the endocrine system, in particular, whether anabolic hormones and their decline over time may be some of the key factors leading to frailty.

In my presentation I will refer to data from two human cohort studies, including the longitudinal European Male Ageing Study, one of the largest studies of male ageing in the world.


Agnieszka Swiecicka-Mitsides MD, MRCP(UK), PhD is an Assistant Professor at the University of Nicosia Medical School.  She completed her specialty training in the United Kingdom where she has subsequently worked as a Consultant in Endocrinology, Diabetes and General Internal Medicine.

She was awarded a PhD in Endocrinology from the University of Manchester, United Kingdom, in 2019 for her research into the role of endocrine factors in unsuccessful ageing and frailty in men. Her work, presented at international conferences, attracted media attention and was subject to press release and press conference in the USA. She published her research in high impact journals and authored book chapters in her area of clinical and academic interest which include reproductive endocrinology, andrology and infertility.

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